New PDF release: Annual Review of Immunology Volume 2 1984

By WILLIAM E PAUL

ISBN-10: 0824330021

ISBN-13: 9780824330026

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Additional resources for Annual Review of Immunology Volume 2 1984

Example text

Rev. 2:51-66 Copyright © 1984 by Annual Reviews Inc. This fact has considerably complicated our understanding of antigen recognition by T cells, a situation obviousin the literature of the last decade on the T-cell receptor for antigen. Mucheffort has goneinto characterization of the T-cell receptor basedon its presumedsimilarity to immunoglobulin, the antigen receptor on B lymphocytes. In general, studies have focused on the characterizationof antibody-likefactors, isolated fromT cells, that are involved in antigen recognition and that apparently bind antigen in the absence of MHC products.

HUMANT-CELL RECEPTOR 45 The[3 chains, unlike the o~ chains, werenot well digested by trypsin. Therefore, to makean adequate comparisonof the. 13 chains of CT8I~and CT4~I, proteolysis with pepsin was required. As demonstratedin Figure 7 (D and E) and in contrast to the similarity of the Ti a chain, the peptide mapsof the two 13 chains were dissimilar in overall appearance and shared only two minor spots. This was again confirmedin mixing experiments(Figure 7F). It is also important to note that parallel analysis of pepsin digestion of Ti~ and Ti2 a and 13 chains indicated that the individual subunits were comprisedof totally distinct peptides and thus bore no precursor-productrelationship (52).

That this is indeed the case is demonstratedin Table 9. A T3 + T8 + T4- tumor-specific and MHC-unrestrictedclone termed JT10, which was established independently from JT9, also reacted with the antiNKTaanticlonotype and displayed an identical pattern of cytotoxic activity towarda panel of 15 tumorcell lines tested. Note that an additional clone, JT3, whichis anti-NKTaunrea~tive, had a quite distinct target specificity. Takentogether, these studies indicated that MHC-unrestricted,tumor-specific T lymphocytes employ Ti-analogous, T3-associated clonotypes (NKT)for target recognition and discrimination (47).

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Annual Review of Immunology Volume 2 1984 by WILLIAM E PAUL


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