By Robert F. Mullins, Jessica M. Skeie (auth.), Iok-Hou Pang, Abbot F. Clark (eds.)
Affecting over 100 million members all over the world, retinal ailments are one of the major factors of irreversible visible impairment and blindness, and acceptable examine types, specially animal versions, are necessary to furthering our realizing of the etiology, pathology, and development of those endemic illnesses. In Animal types for Retinal Diseases, famous specialists within the box spotlight helpful concepts in addition to animal types for the admired retinal illnesses that allows you to relief within the review, improvement, and development of healing suggestions. starting with an summary of the morphology of the retina, visible habit, and genetics and genomics techniques for retinal learn, the publication maintains through overlaying animal types for the learn of particular human retinal illnesses, e.g., retinal degeneration, age-related macular degeneration, retinopathy of prematurity, diabetic retinopathy, glaucoma, retinal ischemia, and retinal irritation. As a quantity within the winning Neuromethods sequence, the chapters supply authoritative experiences of the main conventional techniques within the field.
Vital and straightforward to take advantage of, Animal types for Retinal Diseases serves to aid the real destiny study of ocular investigators, ophthalmologists, and neuroscientists presently delving into this interesting box of study.
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Extra info for Animal Models for Retinal Diseases
Behav Neurosci 111: 792–800 Jacobs GH, Williams GA, Fenwick JA (2004) Influence of cone pigment coexpression on spectral sensitivity and color vision in the mouse. Vis Res 44:1615–1622 Williams GA, Jacobs GH (2007) Cone-based vision in the aging mouse. Vis Res 47: 2037–2046 Jacobs GH, Williams GA, Cahill H, Nathans J (2007) Emergence of novel color vision in mice engineered to express a human cone photopigment. Science 315(5819):1723–1725 Keller J, Strasburger H, Cerutti DT, Sabel BA (2000) Assessing spatial vision - automated measurement of the contrast-sensitivity function in the hooded rat.
Douglas RM, Neve A, Quittenbaum JP, Alam NM, Prusky GT (2006) Perception of visual motion coherence by rats and mice. Vis Res 46:2842–2847 McGill TJ, Douglas RM, Lund RD, Prusky GT (2004) Quantification of spatial vision in the Royal College of Surgeons rat. Invest Ophthalmol Vis Sci 45:932–936 McGill TJ, Lund RD, Douglas RM, Wang S, Lu B, Prusky GT (2004) Preservation of vision following cell-based therapies in a 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 23 model of retinal degenerative disease.
These experiments show that the degenerative process likely proceeds independently in the RPE and the photoreceptors, an important consideration when developing therapeutic strategies for human CHM patients. 5. Generating a Knockout for Every Gene in the Mouse Genome Generating a targeted knockout can be expensive and time consuming for individual research labs and so efforts are underway to generate a knockout for every gene in the mouse genome. org) is initially targeting approximately 10,000 genes, either by completely removing the functional protein, or generating a conditional allele.
Animal Models for Retinal Diseases by Robert F. Mullins, Jessica M. Skeie (auth.), Iok-Hou Pang, Abbot F. Clark (eds.)